HH INHIBITION WITH ITRACONAZOLE

HEDGEHOG INHIBITION WITH ITRACONAZOLE

HEDGEHOG INHIBITION WITH ITRACONAZOLE GRAPHIC

PTCH inhibits SMO in the absence of Hedgehog ligand in normal tissue

HEDGEHOG INHIBITION WITH ITRACONAZOLE GRAPHIC

Hh ligand binding to PTCH releases SMO and Gli1 is expressed, and cancer develops

HEDGEHOG INHIBITION WITH ITRACONAZOLE GRAPHIC

Itraconazole (IT) binds to smoothened (SMO) to inhibit activation of the Gli-1 pathway which leads to the formation of cancerous tumors

HEDGEHOG INHIBITION WITH ITRACONAZOLE GRAPHIC

PTCH is mutated in BCCNS and does not inhibit SMO which leads to Gli1 expression (BCC)

HEDGEHOG INHIBITION WITH ITRACONAZOLE GRAPHIC

Itraconazole binds to SMO and prevents activation of the Gli1 pathway which causes BCC tumors